Principles and Applications of Molecular Diagnostics

Principles and Aspects of Molecular Diagnostics is an accessible guide for clinical chemists and biologists applying molecular technology to clinical diagnosis. The book consists of two parts, with Part One covering principles and analytical concepts in molecular diagnostics, such as genomes and variants, nucleic acids isolation and techniques, circulating tumor cells and DNA, and cellular DNA. Part Two presents clinical applications of molecular diagnostics in solid tumors, prenatal diagnosis, infectious disease, genetic disease, hematopoietic malignancies, pharmacogenetics and identity testing. This book is ideal for those who need a thorough, yet succinct, guide on the use of this technology for molecular testing.

Key Features:

• Explains the principles and tools of molecular biology, along with the modern analytical tools that can be used to obtain the best results.
• Offers authoritative information written and edited by the top experts in molecular diagnostics.
• Provides references to seminal books, review articles and technical articles that go into greater depth, thus serving as the basis for further study.

Περιεχόμενα:

1. Principles of molecular biology, Howe
2. Genomes and variants, Wittwer, Park
3. Nucleic acid isolation, Thatcher
4. Nucleic acid techniques, Wittwer, Makrigiorgos
5. Molecular microbiology, Nolte
6. Genetics, Vnencak-Jones, Best
7. Solid tumor genomics, Mardis
8. Genetic aspects of hematopoietic malignancies, Kelley, Patel
9. Circulating tumor cells, Lianidou, Hoon
10. Circulating nucleic acids for prenatal diagnostics, Chiu, Lo
11. Pharmacogenetics, McMillin, Wadelius, Pratt
12. Identity testing, Weedn, Gettings, Podini