Molecular Pathology: The Molecular Basis of Human Disease, 2nd Edition

As the molecular basis of human disease becomes better characterized and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine.

The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular and cell biology which molecular pathology translates in the practice of molecular medicine.  The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states.

Key Features:

• Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease and how the molecular pathogenesis of disease parallels the evolution of the disease
• Explains the practice of “molecular medicine” and the translational aspects of molecular pathology
• Teaches from the perspective of “integrative systems biology”
• Enhanced digital version included with purchase

Περιεχόμενα:

1. Molecular Mechanisms of Cell Death2. Acute and Chronic Inflammation Induces Disease Pathogenesis3. Infection and Host Response4. Neoplasia

   5. Basic Concepts in Human Molecular Genetics

   6. The Human Genome: Implications for the Understanding of Human Disease

   7. The Human Transcriptome: Implications for the Understanding of Human Disease

   8. The Human Epigenome: Implications for the Understanding of Human Disease

   9. Clinical Proteomics and Molecular Pathology

   10. Integrative Systems Biology: Implications for the Understanding of Human Disease

   11. Pathology: The Clinical Description of Human Disease

   12. Understanding Molecular Pathogenesis: Implications for Improved Treatment of Human Disease

   13. Integration of Molecular and Cellular Pathogenesis: A Bioinformatics Approach

   14. Molecular Basis of Cardiovascular Disease

   15. Molecular Basis of Hemostatic and Thrombotic Diseases

   16. Molecular Basis of Lymphoid and Myeloid Diseases

   17. Molecular Basis of Diseases of Immunity

   18. Molecular Basis of Pulmonary Disease

   19. Molecular Basis of Diseases of the Gastrointestinal Tract

   20. Molecular basis of Liver Disease

   21. Molecular basis of diseases of the exocrine pancreas

   22. Molecular Basis of Diseases of the Endocrine System

   23. Molecular Basis of Gynecologic Diseases

   24. Molecular Basis of Kidney Disease

   25. Molecular Pathogenesis of Prostate Cancer

   26. Molecular Biology of Breast Cancer

   27. Molecular Basis of Skin Disease

   28. Molecular Basis of Bone diseases

   29. Molecular Basis of Diseases of the Nervous System

   30. Molecular Diagnosis of Human Disease

   31. Molecular Assessment of Human Disease in the Clinical Laboratory

   32. Pharmacogenomics and Personalzed Medicine in the Treatment of Human Disease