Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics, 5th Edition

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.

Using the hallmarks of cancer as a starting point, the book looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving the reader a clear appreciation of how our understanding of the theory can be translated into new approaches for tackling the disease.

The new edition draws on the latest research in cancer biology, highlighting fundamental concepts and re-emphasising pre-existing concepts. The book features a variety of learning features – ‘Pause and think’, ‘How do we know that?’, self-tests and activities – to help students engage with, and master, the concepts presented. The emphasis is on acquiring a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit.

Περιεχόμενα:

1:Introduction
2:The cancer genome
3:Regulation of gene expression
4:Growth factor signaling and oncogenes
5:The cell cycle
6:Tumor suppressor genes
7:Apoptosis
8:Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias
9:Metastasis
10:Angiogenesis
11:Reprogrammed metabolism and diet
12:Tumor immunology and immunotherapy
13:Inflammation, infection, and the microbiome
14:Strategies and tools for research and drug development