A Comprehensive Guide to Rodent Models of Liver Diseases

A Comprehensive Guide to Rodent Models of Liver Diseases provides the why, what, and how of preclinical models of liver disease. These models have not only substantially improved understanding of human liver disease pathogenesis, but also helped in developing and testing newer therapeutics as well as addressed some of the unanswered medical challenges and problems of today. This important reference gives a detailed and in-depth review of the various animal models of human liver disorders. Well-reported animal models several human liver diseases such as fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, cholestasis, fibrosis, cirrhosis and its complications are described. Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, brief protocols, relevance, and limitations are provided. Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, updated protocols, relevance, and limitations are provided for consideration. Finally, it provides an overview of the recently developed organoid models of liver pathology.

Περιεχόμενα:

1. An Overview and Pathophysiology of Liver Diseases
2. Animal Models for Liver Research: History and Relevance
3. Small Animal Models for Studying Liver Regeneration
4. Animal Models of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis
5. Animal Models of Alcoholic Liver Disease
6. Preclinical Models of Liver Fibrosis, Portal Hypertension, Cirrhosis and Failure
7. Small Animal Models of Cholestatic Liver Disease
8. Rodent Animal Models of Hepatocellular Carcinoma
9. Preclinical Models of Liver Disease: The Way Ahead